Celldi's core technologies are conjugation and encapsulation.
Two different techniques apply for conjugation and encapsulation new and existing compounds and potency compounds. The mechanism of drugs are released in the human body is different, and makes an effect.
It can be described as an efficient drug delivery technology, and the new drug that binds to Celldi's polymer and the existing used compound, such as dopamine compound, can be called an modified or improved new drug.
Celldi's own polymers are structurally designed such as specific compounds, peptides, or new drug candidates to create a single compound through the combination of Celldi's polymers and candidate compounds.
Such a new polymer-based single compound, through the reaction of specific enzymes present in vivo, breaks the bond between the celldi polymer and the compound and the compound becomes effective in vivo.
Celldi's encapsulation technology is that nanogels capture a single compound.
Nanogel is a type of macromolecular polymer that traps biologically active compounds or molecules of relatively large size.
When entering the body in this state, the reticulum gel breaks down due to the reaction of enzymes present in the body, and the drug is released to show activity.
Polymer-Drug Synthesis Strategies
Determination of conjugation or encapsulation depending on the type of compound structure, size, and water solubility
Conjugation or Encapsulation
PSI is a water-insoluble polymer and acts as a base polymer of poly (asparamide) by ring opening reaction. PSI was synthesized by thermal polycondensation on a mixture of L-aspartic acid monomer and o-phosphoric acid, an acid catalyst.
In the alkaline solution, the poly (aspartame) is produced as α- or β-carboxylate groups, while the ring-opening reaction is alkaline hydrolysis in the PSI's imide group.
III. NMR & FT-IR
NMR analysis is used to verify the binding of active compound conjugates and polymers.
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i. Redox sensitive ii. Redox and pH sensitive
Reduction & pH
Nanogel preparation & Cross linking
Two kinds of redox-sensitive PASP nanogels were prepared. One contains only disulfide bonds as crosslinking agent (type I), and the other contains both redox inert and disulfide bonds (type II). For type I nanogels, PASP-SH was crosslinked by oxidation through NaBrO3. For type II nanogels, some thiol groups in PASP-SH were crosslinked with permanent crosslinker molecules, and the remaining thiol groups gave the nanogels redox.
A “nano emulsion schematic” representation of a PASP SS nanogel.